Association between NLPR1, NLPR3, and P2X7R Gene Polymorphisms with Partial Seizures
Table 5
Genotypic and allelic distribution of the NLRP3 gene between all patients and controls .
SNP
Genotype/allele
Case (%)
Control (%)
value
OR (95% CI)
value
rs4612666
CC
44 (27.0)
59 (29.4)
0.220 (3.026)
1.00
Referent
CT
90 (55.2)
94 (46.8)
0.779 (0.479–1.266)
0.313
TT
29 (17.8)
48 (23.9)
1.234 (0.675–2.258)
0.495
CT + TT
119 (73.0)
142 (70.6)
0.584 (0.300)
0.890 (0.562–1.410)
0.619
C
178 (54.6)
212 (52.7)
0.616 (0.252)
1.00
Referent
T
148 (45.4)
190 (47.3)
1.078 (0.804–1.445)
0.616
rs10754558
CC
50 (30.7)
76 (37.8)
0.313 (2.322)
1.00
Referent
CG
84 (51.5)
89 (44.3)
0.697 (0.438–1.110)
0.128
GG
29 (17.8)
36 (17.9)
0.817 (0.446–1.496)
0.512
CG + GG
113 (69.3)
125 (62.2)
0.155 (2.025)
0.728 (0.470–1.128)
0.155
C
184 (56.4)
241 (60.0)
0.340 (0.912)
1.00
Referent
G
142 (43.6)
161 (40.0)
0.866 (0.644–1.164)
0.340
rs2027432
CC
151 (92.6)
180 (89.5)
0.549 (1.200)
1.00
Referent
CT
11 (6.8)
20 (10.0)
1.525 (0.708–3.284)
0.281
TT
1 (0.6)
1 (0.5)
0.839 (0.052–13.525)
0.901
CT + TT
12 (7.4)
21 (10.5)
0.308 (1.040)
1.468 (0.699–3.082)
0.310
C
313 (96.0)
380 (94.5)
0.352 (0.867)
1.00
Referent
T
13 (4.0)
22 (5.5)
1.394 (0.691–2.812)
0.354
CI, confidence interval; OR, odds ratio. value for genotype and allele frequencies in cases and controls using 2-sided test. values adjusted by age and gender using logistic regression.
