BioMed Research International / 2017 / Article / Tab 4

Research Article

Insulin Resistance in Early Rheumatoid Arthritis Is Associated with Low Appendicular Lean Mass

Table 4

Characteristics of non-insulin-resistant and insulin-resistant early RA patients.

Insulin resistance value

Age, years51 (2)54 (2)NS
 Male, (%)7 (17.1)19 (37.3)0.02
BMI, Kg/m226.3 (0.8)27.9 (0.9)NS
CRP, mg/l8.6 (3.0)14.5 (2.4)0.01
TNF-alpha, pg/ml2.1 (0.1)3.4 (0.4)0.001
IL-6, pg/ml8.6 (4.2)23.2 (5.3)<0.001
RF positive, (%)25 (61.0)39 (76.5)NS
Anti-CCP positive, (%)25 (61.0)38 (74.5)NS
DAS28 score, units3.6 (0.2)4.6 (0.2)0.003
Low disease activity, (%)18 (45.0)11 (21.6)0.02
Moderate disease activity, (%)18 (43.9)18 (35.3)NS
High disease activity, (%)5 (12.2)22 (43.1)0.001
GCS usage
 Current user, (%)10 (25.0)16 (31.4)NS
DMARD usage
 Current user, (%)24 (58.5)27 (52.9)NS
Disease duration, days234.7 (37.5)199.5 (32.3)NS
Total fat mass, Kg26.2 (1.7)28.1 (1.6)NS
FMI, Kg/m29.5 (0.6)10.6 (0.7)NS
FFM, Kg46.4 (1.2)48.0 (1.4)NS
FFMI, Kg/m216.6 (0.3)17.4 (0.3)NS
ALM, Kg18.7 (0.6)19.3 (0.6)NS
ALMI, Kg/BMI0.73 (0.03)0.72 (0.03)NS

Values represent mean ± SE if not stated otherwise. BMI: body mass index; CRP: C-reactive protein; TNF-alpha: tumor necrosis factor-alpha; IL-6: interleukin 6; RF: rheumatoid factor; DAS28: disease activity score calculated using 28 joints; GCS: glucocorticosteroid; FMI: fat mass index (fat mass Kg/height m2); FFM: fat-free mass; FFMI: fat-free mass index (fat free mass/height m2); ALM: appendicular lean mass; ALMI: appendicular lean mass index (appendicular lean Kg/BMI).

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