Tempol, a Superoxide Dismutase Mimetic Agent, Inhibits Superoxide Anion-Induced Inflammatory Pain in Mice

Figure 1

Tempol inhibits KO₂-induced hyperalgesia and paw edema. Mice were treated with tempol (10–100 mg/kg) or vehicle 40 min before KO₂ intraplantar injection. Nociceptive thresholds to mechanical (a) and thermal (b) stimuli as well as paw edema (c) were measured 1–5 h after KO₂ injection. Results are expressed as means ± SEM ( per group per experiment, representative of two separate experiments) [ versus saline; versus KO₂ + vehicle; versus KO₂ + tempol 10 mg/kg; versus KO₂ + tempol 30 mg/kg (ANOVA followed by Tukey’s -test)].

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(b)

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