| | Study (year) | Country | Patients | Included period | Age (range) (year) | Gender (M/F) | Cut-off (mg/dL) | FU (range) (year) | Cofactors | NOS score |
| | Du et al._2013 | China | 286 | 2000–2003 | Median: 55.72 (28–77) | 185/101 | 400 | Median: 56 (34.6–94.5) | Hemoglobin, calcium, LDH, pT stage, Fuhrman grade, tumor size | 7 | | Pichler et al._2013 | Austria | 994 | 2000–2010 | Mean () | 599/395 | 466 | Mean: 48.1 (0–132) | Age, gender, pT stage, Fuhrman grade, necrosis | 8 | | Erdem et al._2014 | Turkey | 128 | 2006–2011 | Mean (58.66 ± 11.31) | 91/37 | 343 | Median: 36.5 | Gender, age, pT stage, Fuhrman grade, tumor size, histologic subtypes, plasma D-dimer | 8 | | Niedworok et al._2015 | Germany | 98 | 2002–2011 | Mean: 63.5 (18–82) | 61/37 | 281 | Mean: 36 (20–122) | NA | 7 | | Sasaki and Onishi_2015 | Japan | 126 | 2003–2013 | Median: 67 (37–86) | 84/42 | 399 | Median: 30.8 (2–125) | PS, pT stage, Hb, Alb, LDH | 8 | | Obata et al._2016 | Japan | 601 | 1995–2010 | Median: 58 (50–67) | 467/134 | 420 | Median: 74 (47–107) | Fuhrman grade, pT stage, histologic subtypes | 8 | | Lee et al._2016 | Korea | 1511 | 2006–2013 | Median: 58 (49–67) | 1077/434 | 328 | Median: 36 (24–57) | Age, BMI, hypertension, diabetes mellitus, ECOG score, tumor size, Fuhrman grade, pT stage, histologic subtypes, tumor necrosis, sarcomatoid differentiation | 8 |
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