The Diagnostic Value of Nuclear Matrix Proteins in Bladder Cancer in the Aspect of Environmental Risk from Carcinogens

Table 7

Evaluated indicators for assessing the reliability of diagnostic tests used in analysis (measures of association and measure of effect) in the whole BC and SA subgroups.

Index	NMP22		BLCA-4		NMBL		GSTπ		8-OHdG
	BC	SA	BC	SA	BC	SA	BC	SA	BC	SA
Sensitivity	57	71	65	69	64	57	81	91	32	55
Specificity	96	80	88	88	96	100	72	72	100	84
ACC	66	75	72	76	73	74	79	84	51	66
PPV	98	86	93	91	98	100	91	85	100	82
NPV	38	63	50	63	51	58	51	82	37	53
LR(+)	14.286	3.571	5.423	5.754	15.873	—	2.904	3.231	—	3.423
LR(−)	0.446	0.357	0.397	0.352	0.380	0.429	0.259	0.132	0.683	0.539
AUC	0.836	0.818	0.830	0.835	0.858	0.862	0.790	0.866	0.637	0.706
Youden index	0.53	0.56	0.53	0.57	0.59	0.60	0.53	0.62	0.32	0.39
Cut-off point	8.53	8.529	1.403	1.4	9.740	10.45	4.342	4.38	18.17	15.322

ACC: accuracy; PPV: positive predictive value; NPV: negative predictive value; LR(+): positive likelihood ratio; (LR−): negative likelihood ratio; AUC: area under the ROC curve; Youden index (0-1) showing the relationship between sensitivity and specificity tests.