Hepatotoxicity of Antimycotics Used for Invasive Fungal Infections: In Vitro Results

Figure 3

Effects of antimycotics agents on the activity of mitochondrial dehydrogenases: XTT test [absorbance/well] in medium. XTT assay of treated hepatocytes with 5.7 mM liposomal amphotericerin B, 2.25 mM anidulafungin, 0.2 mM caspofungin, 4.5 mM fluconazole, and 0.25 mM voriconazole and untreated (negative control) and 15.25 mM APAP (positive control). LDH concentrations in medium of antifungal treated hepatocytes after 144 hours (a) and dose-dependent effects of anidulafungin incubated hepatocytes (b). Results are expressed as median and 25th/75th percentile ( biological and technical repeats). indicates significance of against the negative control.

(a)

(b)