Research Article
Relationship between HLA-DQ Gene Polymorphism and Hepatitis B Virus Infection
Table 1
Characteristics of the studies included in the meta-analysis.
| | First author | Year | Country | Ethnicity | Genotyping method | HBV infection | Control | Natural clearance | Polymorphism | | AA/AG/GG | AA/AG/GG | AA/AG/GG |
| | Mbarek [9] | 2011 | Japan | Japanese | GWAS | 158/226/73 | 477/1001/568 | — | rs2856718 | | 4/72/382 | 67/582/1047 | — | rs7453920 | | First replication | GWAS/invader assay | 209/266/127 | 484/966/572 | — | rs2856718 | | 5/127/471 | 50/575/1397 | — | rs7453920 | | Second replication | TaqMan/GWAS/invader assay | 128/191/62 | 325/746/468 | — | rs2856718 | | 4/75/302 | 53/422/1064 | — | rs7453920 | | Third replication | Invader assay | 465/530/227 | 216/420/243 | — | rs2856718 | | 14/198/1011 | 19/245/615 | — | rs7453920 |
| | Hu [8] | 2012 | China | Chinese Han | TaqMan | 420/674/240 | — | 344/660/331 | rs2856718, | | 5/176/1159 | — | 16/262/1058 | rs7453920 |
| | Hu [11] | 2013 | China | Chinese Han | GWAS | 302/481/168 | — | 273/456/208 | rs2856718 | | 4/128/818 | — | 16/201/685 | rs7453920 | | Replication Ia | TaqMan | 413/606/222 | — | 305/616/309 | rs2856718 | | 7/139/1074 | — | 15/271/954 | rs7453920 | | Replication Ib | TaqMan | 305/493/191 | — | 518/892/392 | rs2856718 | | 8/148/838 | — | 41/397/1365 | rs7453920 | | Replication IIa | TaqMan | 8/96/876 | — | 25/256/1103 | rs7453920 | | Replication IIb | TaqMan | 5/126/842 | — | 18/236/888 | rs7453920 |
| | Al-Qahtani [12] | 2014 | Saudi Arabia | Caucasian | DNA sequencing/TaqMan | 268/205/204 | 127/223/155 | 45/177/73 | rs2856718 | | 144/341/283 | 90/269/223 | 34/145/122 | rs7453920 |
| | Zhang [13] | 2014 | China | Chinese Han | Flight mass spectrometry | 338/345/109 | 163/225/169 | 101/177/72 | rs2856718 |
| | Ji [7] | 2014 | China | Chinese Han | Real-time PCR | 834/1137/422 | 395/686/245 | 101/177/72 | rs2856718 |
| | Liao [14] | 2014 | China | Chinese Han | High resolution melting | 6/48/391 | 5/33/199 | 2/87/32 | s7453920 |
| | Liao [15] | 2015 | China | Tibetans | High resolution melting | 7/96/310 | — | 13/154/319 | rs7453920 |
| | Liao [15] | 2015 | China | Uygurs | High resolution melting | 4/58/128 | — | 17/92/126 | rs7453920 |
| | Liu [16] | 2016 | China | Chinese Han | Flight mass spectrometry | 170/172/54 | 81/112/61 | 50/89/36 | rs2856718 |
| | Gao [17] | 2016 | China | Chinese Han | Flight mass spectrometry | 88/96/33 | 163/225/119 | — | rs2856718 |
| | Trinks [18] | 2017 | Argentina (central) | Caucasian | TaqMan | 62/94/45 | 31/102/74 | 52/158/108 | rs2856718 | | 18/67/116 | 24/85/98 | 34/135/149 | rs7453920 |
| | Trinks [18] | 2017 | Argentina (northwestern) | Caucasian | TaqMan | 73/93/34 | 42/97/62 | 79/142/92 | rs2856718 | | 7/41/52 | 10/59/132 | 22/103/188 | rs7453920 |
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—: No data.
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