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BioMed Research International
Volume 2017, Article ID 9719647, 10 pages
https://doi.org/10.1155/2017/9719647
Research Article

Glycyrrhizin Protects Rats from Sepsis by Blocking HMGB1 Signaling

Department of Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai, China

Correspondence should be addressed to Wei Wang; moc.621@7303iewgnawrd

Received 11 January 2017; Revised 28 February 2017; Accepted 12 March 2017; Published 18 April 2017

Academic Editor: Bo Zuo

Copyright © 2017 Feng Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. S. Hotchkiss and I. E. Karl, “The pathophysiology and treatment of sepsis,” The New England Journal of Medicine, vol. 348, no. 2, pp. 138–150, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. D. C. Angus, W. T. Linde-Zwirble, J. Lidicker, G. Clermont, J. Carcillo, and M. R. Pinsky, “Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care,” Critical Care Medicine, vol. 29, no. 7, pp. 1303–1310, 2001. View at Publisher · View at Google Scholar · View at Scopus
  3. E. K. Stevenson, A. R. Rubenstein, G. T. Radin, R. S. Wiener, and A. J. Walkey, “Two decades of mortality trends among patients with severe sepsis: a comparative meta-Analysis,” Critical Care Medicine, vol. 42, no. 3, pp. 625–631, 2014. View at Publisher · View at Google Scholar · View at Scopus
  4. R. G. Gupta, S. M. Hartigan, M. G. Kashiouris, C. N. Sessler, and G. M. L. Bearman, “Early goal-directed resuscitation of patients with septic shock: current evidence and future directions,” Critical Care, vol. 19, no. 1, article 286, 2015. View at Publisher · View at Google Scholar · View at Scopus
  5. W. J. Wiersinga, S. J. Leopold, D. R. Cranendonk, and T. van der Poll, “Host innate immune responses to sepsis,” Virulence, vol. 5, no. 1, pp. 36–44, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. T. Skirecki, U. Borkowska-Zielińska, M. Złotorowicz, and G. Hoser, “Sepsis immunopathology: perspectives of monitoring and modulation of the immune disturbances,” Archivum Immunologiae et Therapiae Experimentalis, vol. 60, no. 2, pp. 123–135, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. W. J. Kox, T. Volk, S. N. Kox, and H.-D. Volk, “Immunomodulatory therapies in sepsis,” Intensive Care Medicine, vol. 26, supplement 1, pp. S124–S128, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. H. Wang, O. Bloom, M. Zhang et al., “HMG-1 as a late mediator of endotoxin lethality in mice,” Science, vol. 285, no. 5425, pp. 248–251, 1999. View at Publisher · View at Google Scholar · View at Scopus
  9. M. A. D. Van Zoelen, H. Yang, S. Florquin et al., “Role of toll-like receptors 2 and 4, and the receptor for advanced glycation end products in high-mobility group box 1-induced inflammation in vivo,” Shock, vol. 31, no. 3, pp. 280–284, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. W. S. Yang, N. J. Han, J. J. Kim, M. J. Lee, and S.-K. Park, “TNF-α activates high-mobility group box 1—toll-like receptor 4 signaling pathway in human aortic endothelial cells,” Cellular Physiology and Biochemistry, vol. 38, no. 6, pp. 2139–2151, 2016. View at Publisher · View at Google Scholar · View at Scopus
  11. K. Suda, Y. Kitagawa, S. Ozawa et al., “Anti-high-mobility group box chromosomal protein 1 antibodies improve survival of rats with sepsis,” World Journal of Surgery, vol. 30, no. 9, pp. 1755–1762, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. W. Li, M. Ashok, J. Li, H. Yang, A. E. Sama, and H. Wang, “A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1,” PLoS ONE, vol. 2, no. 11, Article ID e1153, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. C. Ye, J.-G. Choi, S. Abraham et al., “Human macrophage and dendritic cell-specific silencing of high-mobility group protein B1 ameliorates sepsis in a humanized mouse model,” Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 51, pp. 21052–21057, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. J.-y. Li, H.-y. Cao, P. Liu, G.-h. Cheng, and M.-y. Sun, “Glycyrrhizic acid in the treatment of liver diseases: literature review,” BioMed Research International, vol. 2014, Article ID 872139, 15 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. L. Mollica, F. De Marchis, A. Spitaleri et al., “Glycyrrhizin binds to high-mobility group box 1 protein and inhibits its cytokine activities,” Chemistry and Biology, vol. 14, no. 4, pp. 431–441, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. W. Wang, F. Zhao, Y. Fang et al., “Glycyrrhizin protects against porcine endotoxemia through modulation of systemic inflammatory response,” Critical Care, vol. 17, no. 2, article R44, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. H. Zhao, M. Zhao, Y. Wang, F. Li, and Z. Zhang, “Glycyrrhizic acid prevents sepsis-induced acute lung injury and mortality in rats,” Journal of Histochemistry and Cytochemistry, vol. 64, no. 2, pp. 125–137, 2016. View at Publisher · View at Google Scholar · View at Scopus
  18. G. Şener, H. Toklu, F. Ercan, and G. Erkanli, “Protective effect of β-glucan against oxidative organ injury in a rat model of sepsis,” International Immunopharmacology, vol. 5, no. 9, pp. 1387–1396, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. National Academy of Sciences, Guide for the Care and Use of Laboratory Animals, National Academy of Sciences, Washington, DC, USA, 2011.
  20. K. J. Livak and T. D. Schmittgen, “Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method,” Methods, vol. 25, no. 4, pp. 402–408, 2001. View at Google Scholar
  21. M. Bosmann and P. A. Ward, “The inflammatory response in sepsis,” Trends in Immunology, vol. 34, no. 3, pp. 129–136, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. M. Kim, H. J. Kim, and K. C. Chang, “Glycyrrhizin reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and endotoxemic mice by p38/Nrf2-dependent induction of HO-1,” International Immunopharmacology, vol. 26, no. 1, pp. 112–118, 2015. View at Publisher · View at Google Scholar · View at Scopus
  23. G. A. Duque and A. Descoteaux, “Macrophage cytokines: involvement in immunity and infectious diseases,” Frontiers in Immunology, vol. 5, article 491, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. M. T. Lotze and K. J. Tracey, “High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal,” Nature Reviews Immunology, vol. 5, no. 4, pp. 331–342, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. J. R. Van Beijnum, W. A. Buurman, and A. W. Griffioen, “Convergence and amplification of toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1),” Angiogenesis, vol. 11, no. 1, pp. 91–99, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. C.-H. Hou, Y.-C. Fong, and C.-H. Tang, “HMGB-1 induces IL-6 production in human synovial fibroblasts through c-Src, Akt and NF-κB pathways,” Journal of Cellular Physiology, vol. 226, no. 8, pp. 2006–2015, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. T. Kawai and S. Akira, “Signaling to NF-κB by Toll-like receptors,” Trends in Molecular Medicine, vol. 13, no. 11, pp. 460–469, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. A. Taguchi, D. C. Blood, G. Del Toro et al., “Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases,” Nature, vol. 405, no. 6784, pp. 354–360, 2000. View at Publisher · View at Google Scholar · View at Scopus
  29. W. J. Hubbard, M. Choudhry, M. G. Schwacha et al., “Cecal ligation and puncture,” Shock, vol. 24, supplement 1, pp. 52–57, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. H. Zhao, M. Zhao, Y. Wang, F. Li, and Z. Zhang, “Glycyrrhizic acid attenuates sepsis-induced acute kidney injury by inhibiting NF-κB signaling pathway,” Evidence-Based Complementary and Alternative Medicine, vol. 2016, Article ID 8219287, 11 pages, 2016. View at Publisher · View at Google Scholar · View at Scopus
  31. B. Schröfelbauer, J. Raffetseder, M. Hauner, A. Wolkerstorfer, W. Ernst, and O. H. J. Szolar, “Glycyrrhizin, the main active compound in liquorice, attenuates pro-inflammatory responses by interfering with membrane-dependent receptor signalling,” Biochemical Journal, vol. 421, no. 3, pp. 473–482, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. Y. Okuma, K. Liu, H. Wake et al., “Glycyrrhizin inhibits traumatic brain injury by reducing HMGB1-RAGE interaction,” Neuropharmacology, vol. 85, pp. 18–26, 2014. View at Publisher · View at Google Scholar · View at Scopus
  33. C.-X. Wu, L.-X. He, H. Guo, X.-X. Tian, Q. Liu, and H. Sun, “Inhibition effect of glycyrrhizin in lipopolysaccharide-induced high-mobility group box 1 releasing and expression from RAW264.7 cells,” Shock, vol. 43, no. 4, pp. 412–421, 2015. View at Publisher · View at Google Scholar · View at Scopus
  34. W. Li, J. Li, A. E. Sama, and H. Wang, “Carbenoxolone blocks endotoxin-induced protein kinase R (PKR) activation and high mobility group box 1 (HMGB1) release,” Molecular Medicine, vol. 19, no. 1, pp. 203–211, 2013. View at Publisher · View at Google Scholar · View at Scopus