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BioMed Research International
Volume 2017, Article ID 9729107, 12 pages
Review Article

Diagnostic Value of CK-18, FGF-21, and Related Biomarker Panel in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis

1Department of Blood Transfusion, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2Department of Laboratory Medicine, Hubei Provincial Hospital of Integrated Chinese & Western Medicine, Wuhan, China
3Department of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
4School of Medicine, Jianghan University, Wuhan, China

Correspondence should be addressed to Fahu Yuan; nc.ude.nuhj@hfnauy

Received 19 November 2016; Accepted 19 January 2017; Published 23 February 2017

Academic Editor: Kusum Kharbanda

Copyright © 2017 Lei He et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The methodology quality assessment of included studies was shown in Figure S1. Figure S2–S5 indicated the results of analysis on CK-18 reporting sensitivity, specificity and summary ROC curves. Standardised mean differences in FGF-21 concentration between subgroups were shown in Figure S6 and S7. Table S1–S4 demonstrated the study characteristics and test results of included studies, grouped by CK-18, FGF-21 and combined biomarker panel. Table S5 showed the cross-study heterogeneity of different biomarkers.

  1. Supplementary Material