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BioMed Research International
Volume 2017, Article ID 9732136, 7 pages
Research Article

Histological Evidence of the Osseointegration of Fractured Direct Metal Laser Sintering Implants Retrieved after 5 Years of Function

1Department of Medicine and Surgery, Dental School, University of Varese, 21100 Varese, Italy
2Department of Dental Sciences, Vita and Salute University S. Raffaele, 20132 Milan, Italy
3Department of Oral and Biotechnological Science, University G. D’Annunzio, 66013 Chieti, Italy

Correspondence should be addressed to Francesco Mangano; moc.liamg@onagnamodiugocsecnarf

Received 10 March 2017; Accepted 30 July 2017; Published 27 August 2017

Academic Editor: Despina Deligianni

Copyright © 2017 Francesco Mangano et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Direct metal laser sintering (DMLS) is an additive manufacturing technique that allows the fabrication of dental implants layer by layer through the laser fusion of titanium microparticles. The surface of DMLS implants is characterized by a high open porosity with interconnected pores of different sizes; therefore, it has the potential to enhance and accelerate bone healing. To date, however, there are no histologic/histomorphometric studies in the literature evaluating the interface between bone and DMLS implants in the long-term. Purpose. To evaluate the interface between bone and DMLS implants retrieved after 5 years of functional loading. Methods. Two fractured DMLS implants were retrieved from the human jaws, using a 5 mm trephine bur. Both the implants were clinically stable and functioned regularly before fracture. The specimens were processed for histologic/histomorphometric evaluation; the bone-to-implant contact (BIC%) was calculated. Results. Compact, mature lamellar bone was found over most of the DMLS implants in close contact with the implant surface; the histomorphometric evaluation showed a mean BIC% of 66.1% (±4.5%). Conclusions. The present histologic/histomorphometric study showed that DMLS implants were well integrated in bone, after 5 years of loading, with the peri-implant bone undergoing continuous remodeling at the interface.