|
| | Medical condition | Study | Application | Total number of patients and sex if mentioned | Outcome |
|
| Soft tissue | | | | | |
|
| Breast augmentation/reconstruction/ soft tissue defect | | | | | |
|
| | Cosmetic breast augmentation | Yoshimura et al. 2008 [50] | Cell assisted lipotransfer (CAL) of SVF/ASCs and lipoinjection | 40 (female) | Preliminary results suggest efficacy and safety |
|
| | Breast augmentation after breast implant removal | Yoshimura et al. 2010 [51] | Cell assisted lipotransfer of SVF/ASCs and lipoinjection | 15 (female) | Very satisfactory outcome 12 months after application |
|
| | Breast augmentation | Kamakura and Ito [52] | Cell assisted lipotransfer of SVF and lipoinjection | 20 (female) | Patient satisfaction was 75% and physician satisfaction 69% |
|
| | Breast augmentation | Wang et al. 2012 [40] | Cell assisted lipotransfer of ASCs/SVF and lipoinjection | 18 (10 patients completed, 6 months' follow-up) | 6-month postoperative, the breast volume is significantly increased and the breasts’ contour is improved |
|
| | Breast reconstruction | Gentile et al. 2012 [53] | Cell assisted lipotransfer of SVF and lipoinjection | 10 (out of total 23) | 1 year postoperative, 63% maintenance of the contour restoring and of three-dimensional volume compared with the control patients treated with fat graft only |
|
| | Breast augmentation | Peltoniemi et al. 2013 [54] | Water assisted lipotransfer (WAL) enriched with SVF | 10 (out of total 18 patients, females) | No advantage in SVF stem cell enrichment in cosmetic fat transplantation observed: breast augmentation by WAL alone was faster, cheaper, with lower risk of contamination, offered at least an equal take rate |
|
| | Healthy participants | Kølle et al. 2013 [55] | Fat grafting after liposuction enriched with ASCs | 10 (females) | ASCs enriched fat grafts had significantly higher residual volumes; no serious adverse events were noted; procedure of ASCs-enriched fat grafting had excellent feasibility and safety |
|
| | Secondary breast reconstruction | Tissiani and Alonso 2016 [56] | Fat grafts enriched with SVF | 11 (out of total 19, females) | SVF enriched fat grafts have proven to be safe in a 3-year follow-up |
|
| | Various including breast reconstruction, scarring, Parry-Romberg disease, gluteal soft tissue defect, pectus excavatum, polio infection sequel, and dermatofibromatosis | Tiryaki et al. 2011 [57] | Fat grafts enriched with SVF | 29 | Preliminary results suggest SVF enriched fat grafting was safe and may provide superior results compared to traditional fat grafting |
|
| | Burns sequelae and posttraumatic scars | Gentile et al. 2014 [58] | Fat grafts enriched with SVF | 10 (out of total 30) | No complications in any patient; the results were lasting in all cases; all patients were satisfied with the resulting texture, softness, contour; MRI confirmed absence of cyst formation and microcalcification |
|
| | Systemic sclerosis | Granel et al. 2015 [59] | Autologous SVF injection in the finger of systemic sclerosis patients | 12 (females) | 6 month after procedure no severe adverse events occurred; four minor adverse events were reported and resolved spontaneously; significant improvement in hand disability and pain, Raynaud’s phenomenon, finger oedema, and quality of life was observed |
|
| | Systemic sclerosis | Guillaume-Jugnot et al. 2016 [60] | Autologous SVF injection in the finger of systemic sclerosis patients | 12 (female) | 12 months after procedure a significant improvement of finger oedema, skin sclerosis, motion, strength of the hands, and of vascular suppression score was noted |
|
| Facial lipoatrophy/facial defects | | | | | |
|
| | Congenital or acquired facial tissue defects (Barraquer-Simons syndrome; Parry Romberg syndrome; traumatic; facial atrophy; lupus erythematosus) | Sterodimas et al. 2011 [61] | Lipografts enriched with SVF | 10 (out of total 20) | Analysis of patient satisfaction in the first six months clearly demonstrated better results using SVF; by the 18-month evaluation, no statistical difference between the lipograft only or lipograft/SVF treatment in terms of patient satisfaction noted |
|
| | Progressive
hemifacial atrophy (Parry-Romberg disease) | Castro-
Govea et al. 2012 [62] | Cell
assisted lipotransfer of SVF and lipoinjection | 1 (male) | 1 and 12
months postoperative evolution of patient was satisfactory; reduction of severe depression of the frontotemporal region, better volume, and symmetry provided |
|
| | Progressive hemifacial atrophy (Parry-Romberg disease) | Koh et al. 2012 [63] | Microfat grafting enriched with ASCs | 5 (3 females, 2 males) (out of total 10, 5 females, 5 males) | Successful outcomes were evident in all 5 patients receiving microfat grafts and ASCs; survival of grafted fat was better than in patients receiving microfat grafts alone |
|
| | Progressive hemifacial atrophy (Parry-Romberg disease) | Chang et al. 2013 [64] | Fat grafts enriched with SVF | 10 (out of total 20) | After 6 months fat survival and clinical improvement were greater with SVF-supplemented grafting than fat grafting alone |
|
| Wound healing | | | | | |
|
| Radiation atrophy | | | | | |
|
| | Therapy for side effects of radiation treatment with severe symptoms or irreversible function damage | Rigotti et al. 2007 [65] | Repeated lipoaspirate (SVF) injection | 22 (females) | Clinical outcomes led to a systematic improvement or remission of symptoms in all evaluated patients, including otherwise untreatable patients exhibiting initial irreversible functional damage |
|
| Ischaemic wounds | | | | | |
|
| | Critical limb ischemia (CLI) patients with ischemic resting pain in 1 limb with/without nonhealing ulcers and necrotic foot | Lee et al. 2012 [66] | Intramuscularly injection of ASCs | 15 (male) | 6 months after application: significant improvement was noted on pain rating scales and in claudication walking distance; digital subtraction angiography showed formation of numerous vascular collateral networks across affected arteries |
|
| | Chronic ulcers of the lower limbs | Marino et al. 2013
[67] | Injection of SVF to the edges of ulcers | 10 (3 females, 7 males) (out of total 20, 14 males, 6 females) | Reduction in diameter and depth of the ulcer, decrease in pain associated with the ulcer process; in six of 10 cases there was complete healing of the ulcer |
|
