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BioMed Research International
Volume 2017, Article ID 9792363, 6 pages
Research Article

Assessment of Drug-Drug Interaction in Ayder Comprehensive Specialized Hospital, Mekelle, Northern Ethiopia: A Retrospective Study

1Mekelle University, School of Pharmacy, Pharmacoepidemiology and Social Pharmacy Courses and Research Team, Mekelle, Ethiopia
2Department of Pharmacy, Pharmacology and Toxicology Courses and Research Team, Adigrat University, Adigrat, Ethiopia

Correspondence should be addressed to Yared Belete Belay; moc.liamg@betelebderay

Received 13 June 2017; Revised 25 September 2017; Accepted 3 October 2017; Published 8 November 2017

Academic Editor: Yudong Cai

Copyright © 2017 Zeru Gebretsadik et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. Adverse drug interaction is a major cause of morbidity and mortality. Its occurrence is influenced by a multitude of factors. The influences of drug-drug interactions (DDIs) can be minimized through creation of awareness to health care professionals. Objective. The objective of this study was to assess DDIs in Ayder Comprehensive Specialized Hospital (ACSH). Methodology. A retrospective study design was employed on patient prescriptions available in the outpatient department of pharmacy and filled from September 2016 to February 2017 in ACSH. Result. From the 600 prescription records assessed, the average number of drugs on single prescription was 2.73. Regarding the interaction observed 34 (9.63%) prescriptions with major drug-drug interaction, 210 (59.5%) moderate, 87 (24.65%) minor, and 22 (6.22%) unknown were identified. Age category showed significant association to affect the occurrence of DDIs and polypharmacy had statistically significant association with DDIs in bivariate analysis which was lost in adjusted OR. Conclusion. From the current study it can be concluded that nearly half of the prescription ordered in ACSH contained DDIs and from the prescription with interacting medications majority of them had moderate DDIs.