MicroRNA-29b Contributes to Collagens Imbalance in Human Osteoarthritic and Dedifferentiated Articular Chondrocytes

Figure 1

Variation of miR-29b level in human chondrocytes with an altered phenotype. (a) Chondrocytes stimulated with 10 ng/ml of hrIL-1β for 48 h () or subcultured repeatedly on plastic dishes (). (b) Chondrocytes from OA patients undergoing joint arthroplasty (). Quantification was performed by the method using the invariant expression of miR-103, miR-423-3p, and miR-191 as endogenous controls. Data are presented as relative levels with reference to non-OA controls () arbitrarily considered as having a value of 1. Bars show the mean ± SEM. versus unstimulated chondrocytes; versus chondrocytes from non-OA controls ().

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