The Phosphatase Inhibitor Calyculin-A Impairs Clot Retraction, Platelet Activation, and Thrombin Generation

Figure 4

Characteristic changes of the cytosolic Ca²⁺ level of single platelets in relation to TRAP activation. Three typical time courses of the intracellular calcium concentration of platelets: no response to TRAP (a), transient increase in the Ca²⁺ level after the addition of TRAP (b), and no transient change upon CLA pretreatment (c). All curves are values where an increase indicates higher cytosolic calcium levels. Dotted lines mark the time of TRAP addition.

(a)

(b)

(c)