Research Article

The Phosphatase Inhibitor Calyculin-A Impairs Clot Retraction, Platelet Activation, and Thrombin Generation

Table 1

Proportion of platelets responding to activation by TRAP.

SampleTotal number of investigated plateletsCa2+ transient in response to activation by TRAPNo transient change
%%

TRAP-activated PRP1172622.2%
(15.59–30.62%)
9177.8%
(69.38–84.41%)
CLA-preincubated TRAP-activated PRP1220(0.0–3.67%)122100%
(96.33–100.0%)

Numbers in brackets indicate the 95% confidence interval; total number of samples = 13 for each dataset.