RNA-seq Based Transcription Characterization of Fusion Breakpoints as a Potential Estimator for Its Oncogenic Potential

Figure 5

The relative RPKM expression level (y-axis) and iFCR value (x-axis) of parent’s genes. Compared to primary tumors and normal tissues, fusion mutations occurring in breast cancer cell lines tend to be having higher iFCR value. The most frequent prostate cancer fusion mutation TMPRSS2-ERG appears as higher expression level and iFCR value in all three independent patients, and it is closed to the fusion mutation of cancer cell lines. A nonrecurrent tumor fusion mutation UPF3A-CDC16 from patient #9 is increased from 0.06 to 0.33 in the normal counterpart to its tumor sample.