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BioMed Research International
Volume 2017, Article ID 9829487, 11 pages
Research Article

The Impact of Age on Clinical Outcomes of Coronary Artery Bypass Grafting: Long-Term Results of a Real-World Registry

1Cardiac Surgery Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy
2Regional Agency for Health and Social Care, Emilia-Romagna, Italy
3Cardiac Surgery Unit, Surgery Department, Parma Hospital, Parma, Italy
4Cardio-Thoracic-Vascular Department, University Hospital S. Orsola-Malpighi, Bologna, Italy
5Department of Clinical Cardiology and Thoraco Vascular Surgery, Hesperia Hospital, Modena, Italy
6Department of Cardiology and Cardiac Surgery, Villa Maria Cecilia Hospital, Lugo, Ravenna, Italy

Correspondence should be addressed to Francesco Nicolini; ti.rpinu@inilocin.ocsecnarf

Received 27 May 2017; Revised 26 September 2017; Accepted 19 October 2017; Published 20 December 2017

Academic Editor: Betti Giusti

Copyright © 2017 Francesco Nicolini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this retrospective multicenter registry study was to investigate age-dependent trends in mortality, long-term survival, and comorbidity over time in patients who underwent isolated CABG from 2003 to 2015. The percentage of patients < 60 years of age was 18.9%. Female sex, chronic pulmonary disease, extracardiac arteriopathy, and neurologic dysfunction disease were significantly less frequent in this younger population. The prevalence of BMI ≥ 30, previous myocardial infarction, preoperative severe depressed left ventricular ejection fraction, and history of previous PCI were significantly higher in this population. After PS matching, at 5 years, patients < 60 years of age reported significantly lower overall mortality (), cardiac-related mortality (), incidence of acute myocardial infarction (), and stroke rates (). Patients < 60 years required repeated revascularization more frequently than older patients (). Patients < 60 who underwent CABG had a lower risk of adverse outcomes than older patients. Patients < 60 have a different clinical pattern of presentation of CAD in comparison with more elderly patients. These issues require focused attention in order to design and improve preventive strategies aiming to reduce the impact of specific cardiovascular risk factors for younger patients, such as diet, lifestyle, and weight control.