Evidence for Tissue Toxicity in BALB/c Exposed to a Long-Term Treatment with Oxiranes Compared to Meglumine Antimoniate

Figure 1

Chemical structure of main active naphthoquinones and oxiranes. (a) Lapachol (CID 3884; molecular formula, C₁₅H₁₄O₃; molecular weight, 242.274 g/mol); (b) β-lapachone (CID 3885; molecular formula, C₁₅H₁₄O₃; molecular weight, 242.274 g/mol); (c) α-lapachone (CID 72732; molecular formula, C₁₅H₁₄O₃; molecular weight, 242.274 g/mol); (d) plumbagin (CID 10205; molecular formula, C₁₁H₈O₃; molecular weight, 188.182 g/mol); (e) epoxy-α-lapachone (CID 12000280; molecular formula, C₁₆H₁₆O₃; molecular weight, 256.301 g/mol); (f) epoxymethoxy-lawsone (molecular formula, C₁₂H₁₀O₃; molecular weight, 202.210 g/mol) (https://pubchem.ncbi.nlm.nih.gov/compound/12000280#section=Top).

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