Evidence for Tissue Toxicity in BALB/c Exposed to a Long-Term Treatment with Oxiranes Compared to Meglumine Antimoniate

Figure 4

Histopathological analysis of mice heart tissue. Nontreated BALB/c mice presented normal structure (A) and after treatment with epoxy-α-lapachone (B) showed regenerated () and degenerated cardiac fibers () and epoxymethoxy-lawsone resulted in diffuse necrosis areas (C). A difference in the necrosis pattern was noted. In the case of epoxy-α-lapachone there is a more degenerative diffuse necrosis with focal areas of fiber regeneration while with epoxymethoxy-lawsone areas of severe necrosis are seen, but there are regions where the fiber structure is still preserved. Meglumine antimoniate caused moderate mononuclear infiltrates (D). Heart tissues were stained with hematoxylin and eosin. Tissue images are representative of 10-fragment analysis by animals (), for each treatment group. Cardiac muscular fibers (cmf), necrosis (ne), and infiltrates (inf).