Evidence for Tissue Toxicity in BALB/c Exposed to a Long-Term Treatment with Oxiranes Compared to Meglumine Antimoniate

Figure 5

Histopathological analysis of mice kidney tissue. Nontreated BALB/c mice showed regular cortical and medullar regions (A, B) and after treatment with epoxy-α-lapachone showed mononuclear infiltrates near the proximal (p) tubules in focal areas of the cortical region and destructed epithelial lining of distal (d) convoluted tubules (C, D). Degenerate collector tubules were observed in diffuse areas of the medullar region. Epoxymethoxy-lawsone produced mononuclear infiltrates and vascular congestion in diffuse areas (E) and focal areas of vascular congestion and degenerate collector tubules (F). Kidney tissues were stained with hematoxylin and eosin. Tissue images are representative of 10-fragment analysis by animals (), for each treatment group. Collector tubules (tc), degenerate collector tubules (dt), epithelial lining of distal convoluted tubules (d), infiltrates (inf), molecular region (mr), proximal convoluted tubules (p), renal glomerulus (rg), and vascular congestion (vc).