Evidence for Tissue Toxicity in BALB/c Exposed to a Long-Term Treatment with Oxiranes Compared to Meglumine Antimoniate
Table 2
Semiquantitative analysis of histological changes in tissues of mice treated with oxiranes derivate of natural 1,4-naphthoquinones and meglumine antimoniate.
Changes
Epoxy-α-lapachone
Epoxymethoxy-lawsone
Meglumine antimoniate
Lung
Thickening of the alveolar septa
+++
+++
++
Peribronchiolar infiltrates
+++
+++
+++
Perivascular infiltrates
++
++++
+++
Hemorrhage
++
++++
+
Heart
Necrosis
++++
+++
+++
Degeneration of cardiac fibers
++++
+++
0
Mononuclear infiltrates
++++
+++
+++
Kidney
Disorganization of the proximal and distal tubules
+++
++
++
Destructed epithelial lining of distal convoluted tubules
+++
+++
0
Disorganization collecting tubules regions
+++
++
0
Cortical infiltrates
++
+++
++
Medullar infiltrates
+++
++
++
Cortical hemorrhage
++
0
0
Medullar hemorrhage
+
+
0
Vascular congestion in the cortical area
+
++
0
Vascular congestion in the medullar area
+
+++
0
Liver
Necrosis
+++
++
0
Mononuclear infiltrates
+++
+++
0
Hemorrhage
+
0
0
Edema
+
0
0
Brain/Cerebellum
Mononuclear infiltrates in Pia Mater
++++
++
0
Disorganization of the cortical region
++++
++
0
Reactive gliosis
++++
++
0
Mononuclear infiltrates in parenchyma
++++
++
0
Degeneration in Purkinje Neuron
++++
+++
0
Grades were assigned using a subjective scale of 0 to ++++ for the different changes. 0 = absent, + = mild, ++ = moderate, +++ = severe, and ++++ = severe-diffuse.
