Pterostilbene Induces Cell Apoptosis and Cell Cycle Arrest in T-Cell Leukemia/Lymphoma by Suppressing the ERK1/2 Pathway

Figure 1

Pterostilbene and SCH772984 inhibit the growth of T-cell leukemia/lymphoma cells. (a, b) Jurkat and Hut-78 cells (2 × 10⁵ cells/mL) were plated onto 96-well plates and treated with different concentrations (0, 10, 15, 20, 25, 30, 35, and 40 μM) of pterostilbene for 24 or 48 h. Data were represented as mean ± SD, . , compared to the control group. , compared to the 24 h group. (c) Jurkat and Hut-78 cells were treated with SCH772984 (0, 1, 2, 5, 10, and 20 μM) for 48 h. Data were represented as mean ± SD, . , compared to the control group. (d) Peripheral blood mononuclear cells (PBMCs) were treated with 0, 10, 20, 40, and 80 μM of pterostilbene for 48 h. Data were represented as mean ± SD, . , compared to the control group. The CCK-8 was used to evaluate these cells’ proliferation, with absorbance measured at 450 nm.

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