Anti-Platelet Factor 4/Heparin Antibody Formation Occurs Endogenously and at Unexpected High Frequency in Polycythemia Vera

Table 2

Baseline characteristics of MPN patient cohort. Characteristic parameters of the study population of 127 MPN patients are displayed (mean for age and peripheral blood counts, frequency for all other parameters). Frequencies are indicated in percent of total patients: absolute numbers are given in parentheses.

MPN type	Polycythemia vera	Essential thrombocythemia
Patient cohort	total
Patients ()	76	51
Male ()	42	18
Female ()	34	33
Parameters at diagnosis
Age ()	55.8	53.2
Hematocrit (%)	53.2	41.6
Hemoglobin (g/l)	176.2	139.2
Platelets (G/l)	602.9	984.3
Leukocytes (G/l)	12.4	9.0
Splenomegaly (%)	55.3 (42/76)	41.2 (21/51)
JAK2V617F (%)	84.2 (64/76)	52.9 (27/51)
Thrombohemorrhagic events
Thrombosis	44.7 (34/76)	39.2 (20/51)
Hemorrhage	18.4 (14/76)	3.9 (2/51)
Medications
Antiaggregation	94.7 (72/76)	88.2 (45/51)
Oral anticoagulation	30.3 (23/76)	11.8 (6/51)
Cytoreduction	75.0 (57/76)	68.6 (35/51)