Identification of Phosphohistone H3 Cutoff Values Corresponding to Original WHO Grades but Distinguishable in Well-Differentiated Gastrointestinal Neuroendocrine Tumors

Table 1

Associations of the clinicopathological characteristics of rectal and other gastrointestinal neuroendocrine tumors.

	Rectal NET	Nonrectal NET
	(%)	(%)
Sex			0.148
M	75 (65.2)	13 (50.0)
F	40 (34.8)	13 (50.0)
Age (y)			0.001
<60	98 (85.2)	15 (57.7)
≥60	17 (14.8)	11 (42.3)
Tumor size (cm)			<0.001
0.1–1	111 (96.5)	20 (76.9)
>1	4 (3.5)	6 (23.1)
Tumor depth			0.001
T1	114 (99.1)	21 (80.8)
T2-3	1 (0.9)	5 (19.2)
LN metastasis			0.460
N0	113 (98.3)	25 (96.2)
N1	2 (1.7)	1 (3.8)
Distant metastasis			0.184
M0	115 (100)	25 (96.2)
M1	0 (0.0)	1 (3.8)
Stage			0.007
I	112 (97.4)	22 (84.6)
II-III	3 (2.6)	4 (15.4)
Grade			0.001
G1	96 (83.5)	15 (57.7)
G2	19 (16.5)	9 (34.6)
G3	0 (0.0)	2 (7.7)
Mitosis/10 HPF			<0.001
<2	100 (87.0)	17 (65.4)	0.004
2–20	15 (13.0)	8 (30.8)
>20	0 (0.0)	1 (3.8)
Ki-67 LI (%)			0.002
<3	109 (94.8)	20 (76.9)	0.001
3–20	6 (5.2)	4 (15.4)
>20	0 (0.0)	2 (7.7)
PHH3 MI/10 HPF			0.014
<2	75 (65.2)	16 (61.6)	0.485
2–20	40 (34.8)	9 (34.6)
>20	0 (0.0)	1 (3.8)
Vascular invasion			0.375
Positive	22 (19.1)	7 (26.9)
Negative	93 (80.9)	19 (73.1)
Lymphatic invasion			0.363
Positive	18 (15.7)	6 (23.1)
Negative	97 (84.3)	20 (76.9)
Perineural invasion			0.123
Positive	12 (10.4)	0 (0.0)
Negative	103 (89.6)	26 (100)
Resection margin			1.000
R0	97 (84.3)	22 (84.6)
R1	18 (15.7)	4 (15.4)
Recurrence			0.001
Yes	6 (5.2)	7 (26.9)
No	109 (94.8)	19 (73.1)
Died			0.018
Yes	4 (3.5)	4 (15.4)
No	111 (96.5)	22 (84.6)

NET, neuroendocrine tumor; HPF, high-power field; LI, labeling index; MI, mitotic index. significant. value <0.05.