Identification of Phosphohistone H3 Cutoff Values Corresponding to Original WHO Grades but Distinguishable in Well-Differentiated Gastrointestinal Neuroendocrine Tumors

Table 3

Comparison of clinicopathological features of tumors of grades stratified before and after use of PHH3 MI (≥4/10 HPFs) determining mitotic counts.

Patient number	Sex/age	Location	Size	Mitosis	Ki-67 LI	PHH3 MI	WHO grade	PHH3 grade
1	F/37	Rectum	0.5	0	0.7	4	1	2
2	M/47	Rectum	0.7	2	1.6	2	2	1
3	M/46	Rectum	0.5	2	2.8	1	2	1
4	M/49	Rectum	0.5	0	2.1	5	1	2
5	M/47	Rectum	0.5	0	2.5	6	1	2
6	F/35	Rectum	0.4	0	2	4	1	2
7	M/60	Rectum	1	0	2.4	4	1	2
8	F/55	Rectum	0.5	0	2.5	4	1	2
9	M/21	Rectum	0.5	0	2.5	6	1	2
10	F/56	Stomach	1	1	0.5	4	1	2

MI, mitotic index; HPF, high-power field; LI, labeling index.