PAX3: A Molecule with Oncogenic or Tumor Suppressor Function Is Involved in Cancer

Figure 3

Schematic model explaining various tissue-specific cellular functions of PAX3 in normal and disease conditions. PAX3 regulates cell differentiation, proliferation, migration, and the survival of different cell types through activating several target genes. Ectopic expression of PAX3 in thyroid cancers shows that it can act as a tumor suppressor. PAX3 in association with FOXO3a leads to cellular differentiation and growth inhibition in cancer. Determining tissue-specific effects of PAX3 is necessary to understand its role in disease pathogenesis.