Functional Polymorphisms in IRAKs Are Related to Hepatocellular Carcinoma Risk in Chinese Population

Table 1

Association between three SNPs and HBV-related HCC susceptibility.

Gene	SNP	Major/minor	Case; (1538)	Control; (1465)	HapMap; MAF	Case; MAF	Control; MAF	OR (95% CI)	P
IRAK2	rs3844283	C/G	1178/344/16	1086/349/30	0.19	0.12	0.14	0.87 (0.74–1.02)	0.082	0.085
IRAK3	rs1152888	A/G	261/731/546	252/722/491	0.38	0.41	0.42	0.94 (0.84–1.04)	0.243	0.243
IRAK4	rs4251545	G/A	1198/309/31	1203/250/12	0.07	0.12	0.09	1.30 (1.09–1.54)	0.003	0.003

Note: MAF = minor allele frequency. Major homozygote/heterozygote/rare homozygote between case and control subjects. HapMap (phase II + III Feb 09, on NCBI B36 assembly, dbSNP b126, HapMap-CHB). OR (95% CI) and P are derived from logistic regression analysis after adjusting for age, sex, drinking and smoking status. P value for multiple comparison, using B-H FDR (false discovery rate) method.