Research Article
The Influence of Formulation and Excipients on Propranolol Skin Permeation and Retention
Table 1
Semisolid formulations composition (% w/w).
| | Component | Ointment1 | Ointment2 | Cream1 | Cream2 | Gel |
| | Propranolol HCl | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | | White petrolatum | 99.00 | 34.65 | - | - | - | | Cetostearyl alcohol | - | 29.70 | - | - | - | | Liquid paraffin | - | 34.65 | - | - | - | | Olive oil | - | - | 59.00 | - | - | | Glyceryl monoleate (Peceol®) | - | - | - | 59.00 | - | | Cetyl palmitate | - | - | 7.00 | 7.00 | - | | White beeswax | - | - | 6.00 | 6.00 | - | | Glyceryl monostearate (Cithrol® GMS) | - | - | 2.00 | 2.00 | - | | Poloxamer 407 (Pluronic® F127) | - | - | - | - | 24.75 | | Water | - | - | 25.00 | 25.00 | 74.25 |
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