Research Article
The Influence of Formulation and Excipients on Propranolol Skin Permeation and Retention
Table 1
Semisolid formulations composition (% w/w).
| Component | Ointment1 | Ointment2 | Cream1 | Cream2 | Gel |
| Propranolol HCl | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | White petrolatum | 99.00 | 34.65 | - | - | - | Cetostearyl alcohol | - | 29.70 | - | - | - | Liquid paraffin | - | 34.65 | - | - | - | Olive oil | - | - | 59.00 | - | - | Glyceryl monoleate (Peceol®) | - | - | - | 59.00 | - | Cetyl palmitate | - | - | 7.00 | 7.00 | - | White beeswax | - | - | 6.00 | 6.00 | - | Glyceryl monostearate (Cithrol® GMS) | - | - | 2.00 | 2.00 | - | Poloxamer 407 (Pluronic® F127) | - | - | - | - | 24.75 | Water | - | - | 25.00 | 25.00 | 74.25 |
|
|