Chronic Consumption of Sweeteners and Its Effect on Glycaemia, Cytokines, Hormones, and Lymphocytes of GALT in CD1 Mice

Table 4

Cytokine CD4⁺ T cell response in Peyer's patches from CD1 mice that consumed sweeteners for 12 weeks.

	Baseline	Middle (9th week)				Final (15th week)
		CL	SUC	SUCL	ST	CL	SUC	SUCL	ST
	Mean ± SD; %	Mean ± SD; %	Mean ± SD; %	Mean ± SD; %	Mean ± SD; %	Mean ± SD; %	Mean ± SD; %	Mean ± SD; %	Mean ± SD; %
IFN-
TNF-
IL-4
IL-5
IL-10

The values represent the mean ± SD of percentage of intracellular cytokines (CD3⁺/CD4⁺ T cells) determined by flow cytometry from Peyer's patches of CD1 mice at 3 (baseline), 9 (middle), and 15 (final) weeks of age. One-way was performed to compare the differences between the subgroups. The differences were considered significant with a value of . CL: Control, SUC: Sucrose, SUCL: Sucralose, ST: Stevia, IFN-: interferon-gamma, TNF-: tumor necrosis factor-alpha, IL-4: interleukin 4, IL-5: interleukin 5, and IL-10: interleukin 10.