Review Article

Histopathology in Periprosthetic Joint Infection: When Will the Morphomolecular Diagnosis Be a Reality?

Table 2

Sensitivity, specificity, and positive and negative predictive values.


Cutoff PMN (%) (%)PPV (%)NPV (%)

Mirra et al. (1976) [8]
34510098--
Fehring and McAlister (1994) [9]
107Total1889--
Feldman et al. (1995) [10]33510096--
Athanasou et al. (1995) [11]106190968898
Lonner et al. (1996) [12]175584967098
Lonner et al. (1996) [12]1751084998998
Pace et al. (1997) [13]25582939087
Abdul-Karim et al. (1998) [14]6454397--
Spangehl et al. (1999) [3]202580947496
Pons et al. (1999) [2]8351009894100
Della Valle et al. (1999) [16]525985095
Banit et al. (2002) [17]12110 (knee and hip)67936793
Banit et al. (2002) [17]
5510 (knee)1009682100
Banit et al. (2002) [17]6310 (hip)45925588
Musso et al. (2003) [18]
45550956092
Ko et al. (2005) [20]
40567978691
Wong et al. (2005) [21]
40593776895
Wong et al. (2005) [21]
401086857592
Francés Borrego et al. (2006) [22]
6310 (knee)66898181
Francés Borrego et al. (2006) [22]
8310 (hip)5010010095
Bori et al. (2006) [23]
61550814086
Nuñez et al. (2007) [25]
136585877991
Nilsdotter-Augustinsson et al. (2007) [26]
8558110010087
Della Valle et al. (2007) [27]
10510 (knee)88969193
Bori et al. (2007) [28]
2152810010073
Bori et al. (2007) [28]
21171645081
Kanner et al. (2008) [29]
132529954092
Müller et al. (2008) [30]
37Total94949786
Schinsky et al. (2008) [31]
20110 (hip)73948290
Fink et al. (2008) [32]
145590958896
Savarino et al. (2009) [34]
3118010010080
Morawietz et al. (2009) [36]
14773959184
Tohtz et al. (2010) [37]
528610010094
Miyamae et al. (2013) [39]
861071894297
Ahmadi et al. (2013) [40]
2275 (elbow)51936090
Muñoz-Mahamud et al. (2013) [41]
115 (fracture)1005533100
Grosso et al. (2014) [42]
445 (shoulder)57100--
Grosso et al. (2014) [42]
4410 (shoulder)73100--
Buttaro et al. (2015) [43]
76590948796
Kashima et al. (2015) [44]
7629497--
Kashima et al. (2015) [44]
7658397--

: number of patients, PMN: polymorphonuclear neutrophil, : sensitivity, Sp: specificity, PPV: positive predictive value, NPV: negative predictive value; 23 polymorphonuclear leukocytes in ≥10 HPF (400x). In each HPF, a maximum of 10 polymorphonuclear leukocytes were counted. The sum must be between zero and 100.