Effects of Digeda-4 Decoction on the CYP450 Activities in Rats Using a Cocktail Method by HPLC

Table 1

Regression equation and correlation coefficient for five probe drugs (y = peak area ratio of probe drugs vs IS; x = concentration of probe drugs).

Probe drugs	Regression equation	Correlation coefficient	Linear range (μg/mL)
Theophylline	Y=0.0057x+0.0013	0.9994	0.1-100
Tolbutamide	Y=0.1938x+0.0004	0.9990	0.1-100
Chlorzoxazone	Y=0.0057x+0.0002	0.9999	0.1-100
Omeprazole	Y=0.0102x+0.0189	0.9986	0.1-50
Midazolam	Y=0.056x+0.0274	0.9994	0.1-50