Effects of Digeda-4 Decoction on the CYP450 Activities in Rats Using a Cocktail Method by HPLC
Table 3
Pharmacokinetic parameters of five probe drugs (mean±SD, n=8).
Probe drugs
Parameters
Control group
Digeda group
Positive group
Theophylline
T1/2/h
6.706±1.625
13.917±2.664
2.475±0.358
Cmax/ug.mL−1
31.833±5.611
30.737±5.451
30.025±5.183
/ug.mL−1.h
205.724±37.141
299.091±67.017
71.926±15.443
/ug.mL−1.h
325.588±76.856
568.825±141.842
117.825±21.367
Cl/L.h−1.Kg−1
0.033±0.006
0.020±0.003
0.061±0.012
Tolbutamide
T1/2/h
6.055±1.081
14.947±3.336
4.812±0.930
Cmax/ug.mL−1
35.642±4.106
40.204±6.834
33.572±3.967
/ug.mL−1.h
165.361±31.618
253.703±59.841
66.621±15.387
/ug.mL−1.h
281.315±68.167
541.077±103.628
93.458±22.481
Cl/L.h−1.Kg−1
0.011±0.002
0.005±0.001
0.021±0.004
Chlorzoxazone
T1/2/h
3.259±0.455
4.008±0.617
2.722±0.516
Cmax/ug.mL−1
24.599±2.017
23.246±4.722
22.677±3.294
AUC0~t/ug.mL−1.h
49.731±9.292
54.010±9.468
38.600±8.152
AUC0~∞/ug.mL−1.h
56.041±10.531
65.272±10.513
42.349±9.768
Cl/L.h−1.Kg−1
0.053±0.010
0.041±0.005
0.065±0.018
Omeprazole
T1/2/h
0.163±0.032
0.282±0.046
0.118±0.020
Cmax/ug.mL−1
20.856±3.706
38.558±6.688
16.913±2.631
/ug.mL−1.h
6.923±1.387
13.273±2.634
4.978±0.845
/ug.mL−1.h
7.283±1.311
14.153±2.609
5.344±0.993
Cl/L.h−1.Kg−1
0.480±0.089
0.294±0.054
0.615±0.086
Midazolam
T1/2/h
0.144±0.030
0.199±0.032
0.105±0.016
Cmax/ug.mL−1
2.900±0.491
2.675±0.509
2.556±0.507
/ug.mL−1.h
0.881±0.151
1.166±0.209
0.653±0.095
/ug.mL−1.h
0.928±0.157
1.355±0.309
0.711±0.125
Cl/L.h−1.Kg−1
6.230±1.145
4.183±0.743
6.896±0.964
Comparing Digeda group with the control group, t1/2, half-life time; Cmax, maximum plasma concentration; AUC, the area under the plasma concentration-time curve; CL, plasma clearance. p < 0.05, p < 0.01
