Drug-Target Interaction Prediction via Dual Laplacian Graph Regularized Matrix Completion

Algorithm 1

Iterative algorithm for solving DLGRMC.

Input: Observed DTIs indicator matrix , drug-drug chemical structure similarity matrix

and target-target genomic sequence similarity matrix ,  , parameters , and .

Initialization: , , , , , , , and .

while not converged do

(1) Update by solving Equation (7);

(2) Update by solving Equation (8);

(3) Update by solving Equation (10);

(4) Update multipliers and using Equation (12);

(5) Update parameters and by and ;

(6) Check the convergence conditions: and ;

end while

Output: .