A Novel MLH1 Initiation Codon Mutation (c.3G>T) in a Large Chinese Lynch Syndrome Family with Different Onset Age and mRNA Expression Level

Table 1

The MLH1 mRNA expression level of in the family members.

Family member	Mutation state	CRC state	MLH1 mRNA expression(2-⊿⊿Ct)	Average expression (2-⊿⊿Ct)
III:1	YES	38	0.80041/1.000/1.000	0.93347
II:2	YES	27	0.77876/0.995/0.887	0.88692
III:3	YES	29	0.74267/0.436/0.719	0.632556667
II:5	YES	no	2.1416/0.973/1.339	1.484533333
IV:1	YES	no	2.7604/1.957/2.606	2.441133333
IV:3	YES	no	9.9197/7.469/11.654	9.6809
IV:4	YES	no	1.2054/0.993/1.163	1.120466667
III:5	NO	no	1.5237/1.166/1.159	1.2829
II:1	NO	no	1.1539/1.635/1.304	1.3643
normal control	NO	no	1/0.895/1.576	1.157