Cisplatin-Induced Rodent Model of Kidney Injury: Characteristics and Challenges

Figure 1

Proximal tubules of BALB/c male mice 4 days after a single cisplatin treatment (17 mg/kg ip): (a,b) hydropic degeneration, pycnotic nuclei, increased cytoplasmic vesicles, cytoplasmic vacuolization, apoptosis, necrosis, loss of brush border, and small hyaline droplets in the cytoplasm (PAS, 400x). (c) Evident loss of brush border, necrosis, desquamation and hyaline/proteinaceous casts, hyaline droplets, and dilated tubules (PAS, 200x). (d) Hyaline casts, hydropic degeneration, and necrosis in distal and collecting tubules (PAS, 200x).

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