Cisplatin-Induced Rodent Model of Kidney Injury: Characteristics and Challenges

Figure 2

Cisplatin has immunosuppressive effects and exhibits cytotoxicity to spleen (CFU-S), granulocyte-macrophage (CFU-C) colony-forming units, and mononuclear cells (MNC) in bone marrow and white blood cells (WBC) in F1 CBAxC57BL female mice (cisplatin: 12 mg/kg, single ip), adapted and modified from Nowrousian et al. [101].