Effects of Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Response to Periodontal Treatment in Patients with Rheumatoid Arthritis
Table 4
Response of periodontal parameters to nonsurgical periodontal treatment among RA subgroups divided by the combination of csDMARDs, NSAIDs, and/or steroids.
DMARDs
DMARDs
DMARDs
DMARDs
P
alone
+ NSAIDs
+ steroids
+ NSAIDs
+ steroids
N
8
4
7
13
PI
Pre
1.9 ± 0.6
1.9 ± 0.9
1.7 ± 0.6
1.9 ± 0.7
0.751
Post
1.0 ± 0.5
1.4 ± 0.8
1.0 ± 0.5
1.1 ± 0.6
0.800
Δ
-0.9 ± 0.7
-0.6 ± 0.5
-0.7 ± 0.5
-0.8 ± 0.8
0.838
GI
Pre
1.8 ± 0.6
1.4 ± 0.8
1.3 ± 0.5
1.7 ± 0.7
0.370
Post
0.7 ± 0.6
0.9 ± 0.5
0.7 ± 0.5
0.6 ± 0.6
0.663
Δ
-1.1 ± 0.7
-0.5 ± 0.9
-0.6 ± 0.4
-1.1 ± 0.6
0.074
PD
Pre
3.0 ± 0.3
2.7 ± 0.3
2.9 ± 0.5
3.2 ± 0.6
0.195
Post
2.2 ± 0.3
2.0 ± 0.1
2.3 ± 0.4
2.3 ± 0.4
0.568
Δ
-0.8 ± 0.2
-0.7 ± 0.2
-0.6 ± 0.4
-0.9 ± 0.5
0.499
CAL
Pre
4.3 ± 0.3
3.3 ± 0.5
3.7 ± 0.6
4.1 ± 0.6
0.036
Post
3.2 ± 0.5
2.2 ± 0.1
2.7 ± 0.7
3.0 ± 0.5
0.016
Δ
-1.1 ± 0.4
-1.1 ± 0.5
-1.0 ± 0.5
-1.1 ± 0.5
0.861
BOP
Pre
84.3 ± 22.9
68.3 ± 23.8
69.1 ± 25.5
83.0 ± 24.3
0.167
Post
36.1 ± 19.5
49.1 ± 12.9
34.5 ± 8.7
41.2 ± 29.4
0.609
Δ
-48.2 ± 20.6
-38.9 ± 4.5
-34.6 ± 26.0
-41.8 ± 26.5
0.487
DAS 28-ESR
Pre
4.3 ± 0.9
4.4 ± 1.5
4.0 ± 1.6
4.2 ± 1.4
0.454
Post
4.1 ± 1.0
4.1 ± 0.7
4.1 ± 1.2
3.9 ± 0.8
0.123
Δ
-0.2 ± 1.0
-0.2 ± 1.0
0.1 ± 1.3
-0.2 ± 1.2
0.311
Values are expressed as mean ± SD. Δ is net change after nonsurgical periodontal treatment, calculated by Post-Pre. BOP, bleeding on probing; CAL, clinical attachment level; csDMARDs, conventional synthetic disease-modifying antirheumatic drugs; DAS 28-ESR, disease activity score 28-erythrocyte sedimentation rate; GI, gingival index; NSAIDs, nonsteroidal anti-inflammatory drugs; PD, probing depth; PI, plaque index; RA, rheumatoid arthritis. Kruskal Wallis test, P < 0.05.
