Research Article
Risk Evaluation of Azithromycin-Induced QT Prolongation in Real-World Practice
Table 1
Baseline characteristics of the subjects.
| | | QT prolongation | Severe QT prolongation | | | Case | Control | p-value | Case | Control | p-value |
| | Total | 62007 (15.4) | 340600 (84.6) | | 9353 (2.3) | 393254 (97.7) | | | Sex | | | <.0001 | | | <.0001 | | Men, n (%) | 33112 (53.4) | 174630 (51.3) | | 4519 (48.3) | 203223 (51.7) | | | Women, n (%) | 28895 (46.6) | 165970 (48.7) | | 4834 (51.7) | 190031 (48.3) | | | Age, Mean (SD) | 58.0 (18.3) | 47.9 (19.7) | <.0001 | 61.2 (17.5) | 49.2 (19.8) | <.0001 | | Age, n (%) | | | <.0001 | | | <.0001 | | -29 | 4693 (7.6) | 62653 (18.4) | | 513 (5.5) | 66833 (17) | | | 30-39 | 4468 (7.2) | 46430 (13.6) | | 536 (5.7) | 50362 (12.8) | | | 40-49 | 8244 (13.3) | 60832 (17.9) | | 1092 (11.7) | 67984 (17.3) | | | 50-59 | 11593 (18.7) | 63102 (18.5) | | 1522 (16.3) | 73173 (18.6) | | | 60-69 | 14088 (22.7) | 58161 (17.1) | | 2126 (22.7) | 70123 (17.8) | | | 70-79 | 13966 (22.5) | 39668 (11.6) | | 2482 (26.5) | 51152 (13) | | | 80- | 4955 (8) | 9754 (2.9) | | 1082 (11.6) | 13627 (3.5) | | | Potassium (mEq/l), Mean (SD) | 4.1 (0.6) | 4.2 (0.5) | <.0001 | 4.0 (0.8) | 4.2 (0.5) | <.0001 | | Calcium (mg/dl), Mean (SD) | 8.8 (0.8) | 9.1 (0.6) | <.0001 | 8.6 (1.0) | 9.1 (0.6) | <.0001 | | Azithromycin, n (%) | 402 (0.6) | 903 (0.3) | <.0001 | 402 (4.3) | 903 (0.2) | <.0001 | | Amoxicillin, n (%) | 733 (1.2) | 4751 (1.4) | <.0001 | 733 (7.8) | 4751 (1.2) | <.0001 |
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