Pharmacokinetics and Bioavailability Study of Monocrotaline in Mouse Blood by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry

Table 3

The main pharmacokinetic parameters of MCT after sublingual intravenous and intragastric administration (n=6).

Parameters	Unit	iv (3 mg/kg)	po (15 mg/kg)
	ng/mLh	2991.9 ±789.1	13215.0±5384.2
	ng/mLh	3225.9 ±941.9	13259.7±5403.8
	H	2.6 ±1.2	1.6 ±0.7
	h	4.5 ±3.3	1.6 ±0.7
	h	7.1 ±3.7	2.6 ±1.5
	h	—	0.5±0.0
	L/h/kg	1.0 ±0.4	1.3 ±0.5
	L/kg	9.3 ±3.6	4.5±3.2
	ng/mL	2553.8 ±340.2	9886.5 ±771.3