Effect of Coenzyme Q₁₀ on Insulin Resistance in Korean Patients with Prediabetes: A Pilot Single-Center, Randomized, Double-Blind, Placebo-Controlled Study

Table 2

Changes in biomarkers of insulin resistance and oxidative stress at baseline and 8 weeks.

	Coenzyme Q10 group			Placebo group
	baseline	8 weeks later	p-value	baseline	8 weeks later	p-value
FBS (mg/dL)	108.5±14.6	106.7±13.5	0.58	110.2±11.24	110.6±14.5	0.87
Insulin (μIU/mL)	20.2±19.9	13.4±10.1	0.19	16.0±20.8	10.5±5.3	0.30
(%)	5.9±0.4	6.0±0.5	0.29	6.0±0.5	6.0±0.4	1.00
HOMA-IR	5.5±5.7	3.0±2.5	<.0001	4.5±6.3	3.0±1.6	0.61
HOMA-β-cell	153.8±178.6	110.4±101.7	0.29	117.2±128.2	90.6±48.2	0.98
Coenzyme Q10 (mg/L)	0.7±0.3	2.4±1.2	<.0001	0.6±0.2	1.0±0.8	<.0001
Oxygen free radical (Fort unit)	326.5±71.1	247.1±70.4	<.0001	294.8±64.3	323.4±58.0	<.0001

FBS, fasting blood sugar; , glycated hemoglobin; HOMA-IR, homeostasis model assessment-insulin resistance.