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Figure 2: RAGE knockdown inhibited chemotaxis and adhesion of THP-1 cells exposed to intermittent hypoxia. Knockdown of RAGE in THP-1 cells was verified via qRT-PCR (a) and western blotting (b and c). Representative images with quantification of the results for THP-1 cells (d) transwell migration assay and adhesion assay (e) in presence of MCP-1. Data were represented as mean + SEM. represents significant difference compared with untreated cells under normoxia condition; /#p<.05, /###p<.001. Scale bars indicate 100 μm.