Gallic Acid Attenuates Dimethylnitrosamine-Induced Liver Fibrosis by Alteration of Smad Phosphoisoform Signaling in Rats

Figure 5

Effects of GA on the liver histological structure of rats with DMN-induced liver fibrosis (Masson staining, 100×), n = 8 animals/group, scale bar: 100 μm. The treatments were as follows: (a) control group, (b) DMN (3 mg/kg; 7 mg/kg), (c) DMN + silymarin (100 mg/kg), (d) DMN + GA (25 mg/kg), (e) DMN + GA (50 mg/kg), and (f) DMN + GA (100 mg/kg). Bridging fibrosis, which formed a broad interval (black arrow) separating the liver parenchyma, was found in the DMN group.

(a)

(b)

(c)

(d)

(e)

(f)