Tranexamic Acid for Adults with Melasma: A Systematic Review and Meta-Analysis

Table 2

Risk-of-bias assessment of included randomized controlled trials.

Study; (first author, year)	Adequate sequence generation	Allocation concealment	Blinding of participants	Blinding of assessment	Incomplete outcomes data addressed	Selective reporting	Free of other bias
Atefi 2017	Low	Low	Low	Unclear	Low	Unclear	Unclear
Banihashemi 2015	Unclear	Unclear	High	Unclear	High	Unclear	Unclear
Budamakuntla 2013	Unclear	Unclear	Low	High	High	Unclear	Unclear
Chung 2015	Unclear	Unclear	High	High	Low	Unclear	Unclear
Ebrahimi 2014	Unclear	Unclear	Low	Unclear	Low	Unclear	Unclear
Karn 2012	Low	Unclear	High	High	Low	Unclear	Unclear
Lajevardi 2016	Low	Low	Low	Low	High	Unclear	Unclear
Lu 2017	Low	Unclear	Low	Low	Low	Unclear	Unclear
Padhi 2015	Unclear	High	High	Unclear	Unclear	Unclear	Unclear
Rosario 2017	Low	Low	Low	Low	Unclear	Unclear	Unclear
Saki 2017	Unclear	Unclear	High	Unclear	High	Unclear	Unclear
Sharma 2016	High	Unclear	High	Unclear	Low	Unclear	Unclear
Shin 2013	Unclear	Unclear	High	Low	Low	Unclear	Unclear
Steiner 2009	Unclear	Unclear	High	Low	Unclear	Unclear	Unclear
Thillaikkarasi 2017	Low	High	High	Unclear	Unclear	Unclear	Unclear
Xu 2017	Unclear	High	High	Low	Low	Unclear	Unclear

Risk of bias was assessed with use of the Cochrane risk-of-bias tool.