Prognostic Value of Lactate Dehydrogenase in Patients with Hepatocellular Carcinoma: A Meta-Analysis

Table 3

Meta-analysis of the correlation between LDH and clinicopathological features in HCC patients.

Stratified analysis	No. of studies	No. of patients	Pooled OR	p-value	Heterogeneity
			(95% CI)		I^2 (%)	P-value	Model
Age (old vs. young)	3	875	1.19 (0.99-1.45)	0.070	0	0.894	Fixed
Gender	5	1463	0.68 (0.49-0.95)	0.025	67.2	0.016	random
(male vs. female)
ECOG score	3	311	1.22 (0.88-1.69)	0.232	33.8	0.221	fixed
(1+ 2 vs. 0)
Tumor number	3	1271	1.25 (0.99-1.58)	0.063	51.1	0.129	random
(multiple vs. single)
Child-Pugh Grade	3	916	1.90 (1.47-2.45)	0.000	0	0.951	fixed
(B vs. A)
AFP (high vs. low)	2	547	1.52 (1.26-1.82)	0.000	0	0.384	fixed
Vascular invasion	3	1271	1.59 (1.36-1.86)	0.000	12.9	0.317	fixed
(yes vs. no)
TNM stage	2	802	1.62 (1.28-2.05)	0.000	0	0.875	fixed
(III+IV vs. I+II)
Tumor diameter	2	1152	2.03 (1.23-3.35)	0.006	89.9	0.002	random
(> 5vs. <5)

Notes: LDH: lactate dehydrogenase; NO: number; OR: odds ratio; 95% CI: 95% confidence intervals; ECOG: Eastern Cooperative Oncology Group; AFP: alpha-fetoprotein; TNM: Tumor Node Metastasis.