Research Article
Prognostic Value of Lactate Dehydrogenase in Patients with Hepatocellular Carcinoma: A Meta-Analysis
Table 3
Meta-analysis of the correlation between LDH and clinicopathological features in HCC patients.
| Stratified analysis | No. of studies | No. of patients | Pooled OR | p-value | Heterogeneity | (95% CI) | I2 (%) | P-value | Model |
| Age (old vs. young) | 3 | 875 | 1.19 (0.99-1.45) | 0.070 | 0 | 0.894 | Fixed |
| Gender | 5 | 1463 | 0.68 (0.49-0.95) | 0.025 | 67.2 | 0.016 | random | (male vs. female) |
| ECOG score | 3 | 311 | 1.22 (0.88-1.69) | 0.232 | 33.8 | 0.221 | fixed | (1+ 2 vs. 0) |
| Tumor number | 3 | 1271 | 1.25 (0.99-1.58) | 0.063 | 51.1 | 0.129 | random | (multiple vs. single) |
| Child-Pugh Grade | 3 | 916 | 1.90 (1.47-2.45) | 0.000 | 0 | 0.951 | fixed | (B vs. A) |
| AFP (high vs. low) | 2 | 547 | 1.52 (1.26-1.82) | 0.000 | 0 | 0.384 | fixed |
| Vascular invasion | 3 | 1271 | 1.59 (1.36-1.86) | 0.000 | 12.9 | 0.317 | fixed | (yes vs. no) |
| TNM stage | 2 | 802 | 1.62 (1.28-2.05) | 0.000 | 0 | 0.875 | fixed | (III+IV vs. I+II) |
| Tumor diameter | 2 | 1152 | 2.03 (1.23-3.35) | 0.006 | 89.9 | 0.002 | random | (> 5vs. <5) |
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Notes: LDH: lactate dehydrogenase; NO: number; OR: odds ratio; 95% CI: 95% confidence intervals; ECOG: Eastern Cooperative Oncology Group; AFP: alpha-fetoprotein; TNM: Tumor Node Metastasis.
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