Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2018, Article ID 1750368, 10 pages
Review Article

Toxic Effects of Di-2-ethylhexyl Phthalate: An Overview

1Department of Physiology, Medical College of Nanchang University, Nanchang 330006, China
2International Exchange College of Nanchang University, Nanchang 330006, China
3Jiangxi Provincial Key Laboratory of Reproductive Physiology and Pathology, Medical College of Nanchang University, Nanchang 330006, China

Correspondence should be addressed to Jiaxiang Chen; nc.ude.ucn@gnaixaijnehc

Received 16 October 2017; Revised 13 January 2018; Accepted 28 January 2018; Published 22 February 2018

Academic Editor: Hartmut Jaeschke

Copyright © 2018 Sai Sandeep Singh Rowdhwal and Jiaxiang Chen. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Di-2-ethylhexyl phthalate (DEHP) is extensively used as a plasticizer in many products, especially medical devices, furniture materials, cosmetics, and personal care products. DEHP is noncovalently bound to plastics, and therefore, it will leach out of these products after repeated use, heating, and/or cleaning of the products. Due to the overuse of DEHP in many products, it enters and pollutes the environment through release from industrial settings and plastic waste disposal sites. DEHP can enter the body through inhalation, ingestion, and dermal contact on a daily basis, which has raised some concerns about its safety and its potential effects on human health. The main aim of this review is to give an overview of the endocrine, testicular, ovarian, neural, hepatotoxic, and cardiotoxic effects of DEHP on animal models and humans in vitro and in vivo.