Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2018, Article ID 1756069, 8 pages
https://doi.org/10.1155/2018/1756069
Review Article

Donation after Circulatory Death in Paediatric Liver Transplantation: Current Status and Future Perspectives in the Machine Perfusion Era

1Division of Abdominal Transplantation and Hepatobiliopancreatic Surgery, Bambino Gesù Children’s Research Hospital IRCCS, Rome, Italy
2The Liver Unit, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
3Department of Experimental Medicine and Surgery, Liver Unit, Tor Vergata University of Rome, Rome, Italy

Correspondence should be addressed to Roberta Angelico; moc.liamg@ocilegna.atrebor

Received 21 November 2017; Accepted 14 February 2018; Published 18 March 2018

Academic Editor: Riccardo De Carlis

Copyright © 2018 Roberta Angelico et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Organ Procurement and Transplantation Network; Scientific Registry of Transplant Recipients. OPTN/SRTR 2011 annual data report: liver, 2017 http://srtr.transplant.hrsa.gov/annual_reports/2011.
  2. E. K. Hsu, M. L. Shaffer, L. Gao et al., “Analysis of Liver Offers to Pediatric Candidates on the Transplant Wait List,” Gastroenterology, vol. 153, no. 4, pp. 988–995, 2017. View at Publisher · View at Google Scholar · View at Scopus
  3. R. M. Merion, S. J. Pelletier, N. Goodrich, M. J. Englesbe, and F. L. Delmonico, “Donation after cardiac death as a strategy to increase deceased donor liver availability,” Annals of Surgery, vol. 244, no. 4, pp. 555–560, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. D. S. Goldberg, S. J. Karp, M. E. McCauley et al., “Interpreting outcomes in DCDD liver transplantation: First report of the multicenter IDOL consortium,” Transplantation, vol. 101, no. 5, pp. 1067–1073, 2017. View at Publisher · View at Google Scholar · View at Scopus
  5. R. J. Johnson, L. L. Bradbury, K. Martin, and J. Neuberger, “Organ donation and transplantation in the UK-The last decade: A report from the UK national transplant registry,” Transplantation, vol. 97, no. 1, p. -S27, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. D. Monbaliu, J. Pirenne, and D. Talbot, “Liver transplantation using donation after cardiac death donors,” Journal of Hepatology, vol. 56, no. 2, pp. 474–485, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Maheshwari, W. Maley, Z. Li, and P. J. Thuluvath, “Biliary complications and outcomes of liver transplantation from donors after cardiac death,” Liver Transplantation, vol. 13, no. 12, pp. 1645–1653, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. M. E. de Vera, R. Lopez-Solis, I. Dvorchik et al., “Liver transplantation using donation after cardiac death donors: long-term follow-up from a single center,” American Journal of Transplantation, vol. 9, no. 4, pp. 773–781, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. M. L. Deoliveira, W. Jassem, R. Valente et al., “Biliary complications after liver transplantation using grafts from donors after cardiac death: Results from a matched control study in a single large volume center,” Annals of Surgery, vol. 254, no. 5, pp. 716–722, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. D. P. Foley, L. A. Fernandez, G. Leverson et al., “Donation after cardiac death: the University of Wisconsin experience with liver transplantation,” Annals of Surgery, vol. 242, no. 5, pp. 724–731, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. R. Mateo, Y. Cho, G. Singh et al., “Risk factors for graft survival after liver transplantation from donation after cardiac death donors: An analysis of OPTN/UNOS data,” American Journal of Transplantation, vol. 6, no. 4, pp. 791–796, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Schlegel, I. Scalera, M. T. P. R. Perera et al., “Impact of donor age in donation after circulatory death liver transplantation: is the cutoff "60" still of relevance?” Liver Transplantation, vol. 24, no. 3, pp. 352–362, 2018. View at Google Scholar
  13. R. Ravikumar, W. Jassem, H. Mergental et al., “Liver Transplantation After Ex Vivo Normothermic Machine Preservation: A Phase 1 (First-in-Man) Clinical Trial,” American Journal of Transplantation, vol. 16, no. 6, pp. 1779–1787, 2016. View at Publisher · View at Google Scholar · View at Scopus
  14. P. Dutkowski, W. G. Polak, P. Muiesan et al., “First comparison of hypothermic oxygenated perfusion versus static cold storage of human donation after cardiac death liver transplants,” Annals of Surgery, vol. 262, no. 5, pp. 764–771, 2015. View at Publisher · View at Google Scholar
  15. G. C. Oniscu, L. V. Randle, P. Muiesan et al., “In situ normothermic regional perfusion for controlled donation after circulatory death - The United Kingdom experience,” American Journal of Transplantation, vol. 14, no. 12, pp. 2846–2854, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. P. Moore, I. Kerridge, J. Gillis, S. Jacobe, and D. Isaacs, “Withdrawal and limitation of life-sustaining treatments in a paediatric intensive care unit and review of the literature,” Journal of Paediatrics and Child Health, vol. 44, no. 7-8, pp. 404–408, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. P. Muiesan, W. Jassem, R. Girlanda et al., “Segmental liver transplantation from non-heart beating donors - An early experience with implications for the future,” American Journal of Transplantation, vol. 6, no. 5 I, pp. 1012–1016, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Bartlett, R. Vara, P. Muiesan et al., “A single center experience of donation after cardiac death liver transplantation in pediatric recipients,” Pediatric Transplantation, vol. 14, no. 3, pp. 388–392, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. P. Abt, R. Kashyap, M. Orloff et al., “Pediatric liver and kidney transplantation with allografts from DCD donors: A review of UNOS data,” Transplantation, vol. 82, no. 12, pp. 1708–1711, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. M. T. P. R. Perera, S. Gozzini, D. Mayer et al., “Safe use of segmental liver grafts from donors after cardiac death (DCD) in children with acute liver failure,” Transplant International, vol. 22, no. 7, pp. 757–760, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Gozzini, M. T. P. R. Perera, D. A. Mayer et al., “Liver transplantation in children using non-heart-beating donors (NHBD),” Pediatric Transplantation, vol. 14, no. 4, pp. 554–557, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. T. Gelas, J. Hartley, D. F. Mirza, P. Muiesan, C. Bowen, and K. Sharif, “Segmental ABO-incompatible liver graft from a donor after cardiac death in neonatal acute liver failure,” Pediatric Transplantation, vol. 16, no. 2, pp. E53–E57, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. J. C. Hong, R. Venick, H. Yersiz et al., “Liver transplantation in children using organ donation after circulatory death: A case-control outcomes analysis of a 20-year experience in a single center,” JAMA Surgery, vol. 149, no. 1, pp. 77–82, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. R. van Rijn, P. E. R. Hoogland, F. Lehner, E. L. W. Van Heurn, and R. J. Porte, “Long-term results after transplantation of pediatric liver grafts from donation after circulatory death donors,” PLoS ONE, vol. 12, no. 4, Article ID e0175097, 2017. View at Publisher · View at Google Scholar · View at Scopus
  25. D. I. Isnardi, F. Olivero, R. Lerda, A. Guermani, and G. Cornara, “Extracorporeal membrane oxygenation as a bridge to organ donation: A case report,” Transplantation Proceedings, vol. 45, no. 7, pp. 2619-2620, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Assalino, P. Majno, C. Toso et al., “In situ liver splitting under extracorporeal membrane oxygenation in brain-dead donor,” American Journal of Transplantation, vol. 18, no. 1, pp. 258–261, 2018. View at Publisher · View at Google Scholar
  27. J. G. Brockmann, T. Vogel, C. Coussios, and P. J. Friend, “Liver splitting during normothermic organ preservation,” Liver Transplantation, vol. 23, no. 5, pp. 701–706, 2017. View at Publisher · View at Google Scholar · View at Scopus
  28. Z.-B. Zhang, W. Gao, L. Liu, Y. Shi, N. Ma, and Z.-Y. Shen, “Development and assessment of normothermic machine perfusion preservation for extracorporeal splitting of pig liver,” Annals of Transplantation, vol. 22, pp. 507–517, 2017. View at Publisher · View at Google Scholar · View at Scopus
  29. WHO, “The transplantation society and organizacion nacional de trasplantes,” in Third WHO Global Consultation on Organ Donation and Transplantation: Striving to Achieve Self-Sufficiency, vol. 91 of Transplantation, 11, p. S27, 2011. View at Google Scholar
  30. M. Thuong, A. Ruiz, P. Evrard et al., “New classification of donation after circulatory death donors definitions and terminology,” Transplant International, vol. 29, no. 7, pp. 749–759, 2016. View at Publisher · View at Google Scholar · View at Scopus
  31. P. Murphy, C. Boffa, A. Manara, D. Ysebaert, and W. de Jongh, “In-hospital logistics: what are the key aspects for succeeding in each of the steps of the process of controlled donation after circulatory death?” Transplant International, vol. 29, no. 7, pp. 760–770, 2016. View at Publisher · View at Google Scholar · View at Scopus
  32. P. L. Abt, N. M. Desai, M. D. Crawford et al., “Survival Following Liver Transplantation from Non-Heart-Beating Donors,” Annals of Surgery, vol. 239, no. 1, pp. 87–92, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. C. Lan, J. L. Song, L. N. Yan et al., “Pediatric Donor to Adult Recipients in Donation After Cardiac Death Liver Transplantation: A Single-Center Experience,” Transplantation Proceedings, vol. 49, no. 6, pp. 1383–1387, 2017. View at Publisher · View at Google Scholar · View at Scopus
  34. A. Schlegel, M. Kalisvaart, I. Scalera et al., “The UK DCD Risk Score: A new proposal to define futility in donation-after-circulatory-death liver transplantation,” Journal of Hepatology, vol. 68, no. 3, pp. 456–464, 2018. View at Publisher · View at Google Scholar
  35. J. M. Bellingham, C. Santhanakrishnan, N. Neidlinger et al., “Donation after cardiac death: A 29-year experience,” Surgery, vol. 150, no. 4, pp. 692–702, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. D. M. Ouweneel, J. V. Schotborgh, J. Limpens et al., “Extracorporeal life support during cardiac arrest and cardiogenic shock: a systematic review and meta-analysis,” Intensive Care Medicine, vol. 42, no. 12, pp. 1922–1934, 2016. View at Publisher · View at Google Scholar · View at Scopus
  37. J. F. Magliocca, J. C. Magee, S. A. Rowe et al., “Extracorporeal support for organ donation after cardiac death effectively expands the donor pool,” Journal of Trauma - Injury Infection and Critical Care, vol. 58, no. 6, pp. 1095–1102, 2005. View at Publisher · View at Google Scholar · View at Scopus
  38. X. Fan, Z. Chen, D. Nasralla et al., “The organ preservation and enhancement of donation success ratio effect of extracorporeal membrane oxygenation in circulatory unstable brain death donor,” Clinical Transplantation, vol. 30, no. 10, pp. 1306–1313, 2016. View at Publisher · View at Google Scholar · View at Scopus
  39. A. I. Sánchez-Fructuoso, D. Prats, J. Torrente et al., “Renal transplantation from non-heart beating donors: a promising alternative to enlarge the donor pool,” Journal of the American Society of Nephrology, pp. 350–358, 2000. View at Google Scholar
  40. L. B. Johnson, J. S. Plotkin, C. D. Howell, M. J. Njoku, P. C. Kuo, and S. T. Bartlett, “Successful emergency transplantation of a liver allograft from a donor maintained on extracorporeal membrane oxygenation,” Transplantation, vol. 63, no. 6, pp. 910-911, 1997. View at Google Scholar · View at Scopus
  41. C. Fondevila, A. J. Hessheimer, A. Ruiz et al., “Liver transplant using donors after unexpected cardiac death: Novel preservation protocol and acceptance criteria,” American Journal of Transplantation, vol. 7, no. 7, pp. 1849–1855, 2007. View at Publisher · View at Google Scholar · View at Scopus
  42. A. I. Sánchez-Fructuoso, M. Marques, D. Prats et al., “Victims of cardiac arrest occurring outside the hospital: A source of transplantable kidneys,” Annals of Internal Medicine, vol. 145, no. 3, pp. 157–164, 2006. View at Publisher · View at Google Scholar · View at Scopus
  43. O. Reznik, A. Skvortsov, I. Loginov, A. Ananyev, S. Bagnenko, and Y. Moysyuk, “Kidney from uncontrolled donors after cardiac death with onehour warm ischemic time: Resuscitation by extracorporal normothermic abdominal perfusion "in situ" by leukocytes-free oxygenated blood,” Clinical Transplantation, vol. 25, no. 4, pp. 511–516, 2011. View at Publisher · View at Google Scholar · View at Scopus
  44. M. L. Migliaccio, G. Zagli, G. Cianchi et al., “Extracorporeal membrane oxygenation in brain-death organ and tissues donors: A single-centre experience,” British Journal of Anaesthesia, vol. 111, no. 4, pp. 673-674, 2013. View at Publisher · View at Google Scholar · View at Scopus
  45. S. J.-G. Marchán, J. C. Meneu-Diaz, A. M. Elola-Olaso et al., “Liver transplantation using uncontrolled non-heart-beating donors under normothermic extracorporeal membrane oxygenation,” Liver Transplantation, vol. 15, no. 9, pp. 1110–1118, 2009. View at Publisher · View at Google Scholar · View at Scopus
  46. A. C. Farney, R. P. Singh, M. H. Hines et al., “Experience in Renal and Extrarenal Transplantation with Donation after Cardiac Death Donors with Selective Use of Extracorporeal Support,” Journal of the American College of Surgeons, vol. 206, no. 5, pp. 1028–1037, 2008. View at Publisher · View at Google Scholar · View at Scopus
  47. C.-Y. Lee, M.-K. Tsai, W.-J. Ko et al., “Expanding the donor pool: Use of renal transplants from non-heart-beating donors supported with extracorporeal membrane oxygenation,” Clinical Transplantation, vol. 19, no. 3, pp. 383–390, 2005. View at Publisher · View at Google Scholar · View at Scopus
  48. R. Angelico, M. T. Perera, R. Ravikumar et al., “Normothermic Machine Perfusion of Deceased Donor Liver Grafts Is Associated With Improved Postreperfusion Hemodynamics,” Transplantation Direct, vol. 2, no. 9, p. e97, 2016. View at Publisher · View at Google Scholar
  49. M. Bral, B. Gala-Lopez, D. Bigam et al., “Preliminary Single-Center Canadian Experience of Human Normothermic Ex Vivo Liver Perfusion: Results of a Clinical Trial,” American Journal of Transplantation, vol. 17, no. 4, pp. 1071–1080, 2017. View at Publisher · View at Google Scholar · View at Scopus
  50. T. Perera, H. Mergental, B. Stephenson et al., “First human liver transplantation using a marginal allograft resuscitated by normothermic machine perfusion,” Liver Transplantation, vol. 22, no. 1, pp. 120–124, 2016. View at Publisher · View at Google Scholar · View at Scopus
  51. K. W. Lee, A. M. Cameron, W. R. Maley, D. L. Segev, and R. A. Montgomery, “Factors affecting graft survival after adult/child split-liver transplantation: Analysis of the UNOS/OPTN data base,” American Journal of Transplantation, vol. 8, no. 6, pp. 1186–1196, 2008. View at Publisher · View at Google Scholar · View at Scopus