Absorption of Codonopsis pilosula Saponins by Coexisting Polysaccharides Alleviates Gut Microbial Dysbiosis with Dextran Sulfate Sodium-Induced Colitis in Model Mice

Table 2

Pharmacokinetic parameters of the largest monomer ion pair (m/z 415.2) after oral administration of C. pilosula saponins to mice.

	Fro	Cp	Cs	Con	Mod
Parameter			Oral administration (n = 3)
(h)	6	3	3	6	1
(ppb)	109 ±	98.5 ±	95.7 ±	88.3 ±	69.83 ±
t1/2 (h)	3.53 ± 0.33	4.94 ± 0.44	3.85 ± 0.62	3.49 ± 0.38	3.67 ± 0.5
(ppb h)	884.5 ± 65.5	615.55 ± 60	575.55 ± 78	695.45 ± 64.5	538.56 ± 49.9
(ppb h)	898.77 ±	788.43 ±	748.43 ±	761.74 ±	596.46 ±
(ppb h^2)	5725.48 ± 535	6133.39 ± 478	5473.32 ± 298	6532.63 ± 567	3636.69 ± 357
(h)
Vz/F (L/h kg)	1.70 ± 0.25	2.13 ± 0.24	2.37 ± 0.18	1.46 ± 0.24	2.66 ± 0.37
Cl/F (L/h kg)	0.33 ± 0.06	0.38 ± 0.1	0.41 ± 0.07	0.39 ± 0.05	0.50 ± 0.14

^a–c Data within a column without the same superscripts differ significantly (P < 0.05).
Fro = fructooligosaccharides group, Cp = Codonopsis pilosula polysaccharide group, Cs = Codonopsis pilosula saponins group, Con = control group, and Mod = DSS-induced colitis group.