Prognostic Significance of Serum Lactic Acid, Lactate Dehydrogenase, and Albumin Levels in Patients with Metastatic Colorectal Cancer

Table 3

Univariate analysis of patients with metastatic colorectal cancer (N=57).

Prognostic factors	PFS			OS
	HR	95CI	P value	HR	95CI	P value
Age (56y)	0.892	0.499-1.596	0.701	0.945	0.504-1.794	0.861
Sex (Female)	0.961	0.538-1.717	0.894	0.763	0.404-1.442	0.405
Locations (Rectum)	0.530	0.294-0.953	0.034	0.351	0.178-0.690	0.002
Pathological type (Poorly)	2.340	1.223-4.474	0.010	2.113	1.083-4.124	0.028
Other treatment	0.715	0.368-1.387	0.320	0.952	0.465-1.952	0.894
Regimens of chemotherapy	1.537	0.836-2.823	0.166	1.664	0.856-3.235	0.134
SLA (m mol/L) (≥4.0)	1.873	0.864-4.061	0.112	2.058	0.881-4.807	0.096
S-LDH (m mol/L) (≥225)	2.001	1.038-3.859	0.038	2.481	1.226-5.019	0.011
LDH≥225 and SLA≥4.0	3.711	1.258-10.947	0.018	3.944	1.449-10.733	0.007
Albumin (g/L) (≥40)	0.388	0.216-0.697	0.002	0.384	0.205-0.721	0.003
TP (g/L) (<70)	0.717	0.403-1.278	0.260	0.967	0.518-1.807	0.917
CEA (u g/L) (≥5.0)	1.268	0.722-2.228	0.409	1.078	0.578-2.007	0.814
CA 199 (U/ml) (≥40.0)	2.233	1.219-4.091	0.009	2.201	1.155-4.196	0.017

We define P < 0.05 as statistical difference.